SERUM URIC ACID LEVEL AS A PREDICTOR OF CARDIOVASCULAR RISK - WHAT IS THE EVIDENCE?
DOI:
https://doi.org/10.58043/rphrc.168Keywords:
serum uric acid, cardiovascular risk, predictorAbstract
Introduction: Cardiovascular risk is defined as the probability of an individual developing cardiovascular disease in the future, influenced by well-established risk factors. Since cardiovascular disease is the leading cause of mortality and disability in Western countries, it is essential to manage these factors effectively and investigate the presence of additional contributors.Methods: A narrative review of the scientific literature was conducted to assess the relationship between serum uric acid levels and cardiovascular risk. The study involved a search for articles published between January 1, 2022, and December 31, 2024, in the PubMed®, ScienceDirect®, and Cochrane Library® databases.
Results: Hyperuricemia is associated with an increased cardiovascular risk through its relationship with key risk factors, including chronic kidney disease, diabetes, obesity, left ventricular hypertrophy, and arterial stiffness. Additionally, indexing serum uric acid levels to renal function, using serum creatinine levels, has been shown to enhance its role as a comprehensive biomarker, suggesting its utility in patient screening.
Discussion and Conclusion: Hyperuricemia is considered an additional risk factor for both the development and progression of cardiovascular disease. Early monitoring of serum uric acid levels and appropriate management of hyperuricemia may be fundamental to reduce cardiovascular risk and improve patients’ quality of life.
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Copyright (c) 2025 Inês Rodrigues Gonçalves, Daniel Santos Silva, Luísa Belo Vieira, Andréa Cunha Antunes
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